cresence AS

Journal

Epidermal Growth Factor in the CNS: A Beguiling Journey from Integrated Cell Biology to Multiple Sclerosis. An Extensive Translational Overview

Giuseppe Scalabrino Abstract This article reviews the wealth of papers dealing with the different effects of epidermal growth factor (EGF) on oligodendrocytes, astrocytes, neurons, and neural stem cells (NSCs). EGF induces the in vitro and in vivo proliferation of NSCs, their migration, and their differentiation towards the neuroglial cell line. It interacts with extracellular matrix …

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Prevention Of Clinical And Histological Signs Of MOG-Induced Experimental Allergic Encephalomyelitis By Prolonged Treatment With Recombinant Human EGF

Ferdinando Nicoletti, Emanuela Mazzon, Paolo Fagone, Katia Mangano, Santa Mammana, Eugenio Cavalli, Maria Sofia Basile, Placido Bramanti, Giuseppe Scalabrino, Alois Lange, Francois Curtin Abstract Epidermal growth factor (EGF) represents the prototype of the group I EGF family. The pleiotropic effects of the EGF have attracted attention to the possibility that it could be implicated in …

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